Reversal of ischemic damage with secondary blood cardioplegia.

摘要: After severe ischemic injury, it is usually necessary to prolong bypass enhance recovery. This study tests the hypothesis that best reversal of damage achieved by briefly rearresting postischemic heart with a continuous infusion an oxygenated cardioplegic solution (secondary blood cardioplegia) during period when must be prolonged. Twenty dogs underwent 45 minutes normothermic arrest. Fifteen after unclamping, no could support systemic circulation. In all dogs, oxygen demands were lowered extending for 30 minutes. 10 these further 5 37 degrees C (K+28 mEq/L; pH 7.6; Ca++ 1 mEq/L) at pressure 50 mm Hg. Hearts treated secondary cardioplegia showed greater recovery in rate contraction (-dP/dt 75% versus 62%, p less than 0.05) and relaxation 76% 58%, 0.05), better compliance (85% 51%, higher stroke work index (0.72 0.50 gm-m/Kg, more ability augment uptake 45%, meet working hearts prolonging alone. We conclude brief, results complete possible prolongation believe increased from diversion delivered toward reparative processes rather its being expended needlessly on electromechanical time