Calcium Channel Blockers: The Present and the Future

摘要: Over the past two decades, calcium channel blockers have been used extensively in treatment of hypertension, ischemic heart disease, and supraventricular arrhythmias. Since 1993, they most frequently class antihypertensive drugs; fact, 1995 accounted for 29% all drugs prescribed this patient population.', ' The reasons their extensive use are high degree efficacy; relatively low frequency serious adverse effects; lack effect on serum lipids: insulin resistance, renal hem~dynamics.~ In addition, reduce left ventricular mass hypertensive patients.* purpose editorial is to provide a perspective recent publications evaluating hypertension. I also discuss prospective, randomized trials that currently enrolling patients determine i f cardiovascular morbidity mortality patients. effectiveness reducing blood pressure compared with placebo other has demonstrated clearly widely publicized hypertension years, Treatment Mild Hypertension Study6 Veterans Affairs Cooperative Study Group Antihypertensive Agents.7, Despite impressive performance surrogate end point pressure, not shown nonfatal fatal complications or all-cause trial. fifth Joint National Committee Detection, Evaluation High Blood Pressure