Evidence for Positive Selection in Foot-and-Mouth Disease Virus Capsid Genes From Field Isolates

摘要: The nature of selection on capsid genes foot-and-mouth disease virus (FMDV) was characterized by examining the ratio nonsynonymous to synonymous substitutions in 11 data sets sequences obtained from six different serotypes FMDV. Using a method analysis that assigns each codon position one number estimated values ratio, significant evidence positive identified 5 sets, operating at 1-7% positions. Evidence complete A and C VP1 SAT 1 2. Sequences serotype SAT-2 recovered persistently infected African buffalo also revealed for selection. Locations codons under coincide closely with those antigenic sites previously use monoclonal antibody escape mutants. vast majority are mild strong purifying However, these results suggest arising variants benefit selective advantage their interaction immune system, either during course an infection or transmission individuals previous exposure antigen. Analysis amino acid usage indicates this can be conferred share physicochemically similar properties.