The influence of sex upon the antibody response to an incompatible tumour.

摘要: (BALB/c×C57B1) hybrids and strain 129 hosts of both sexes were immunized with heavily irradiated cells the C3H ascites sarcoma, B.P.8. It was found that primary secondary haemagglutinin responses higher in females than males same strain. After passive immunization, antibody titres declined at equal rates two sexes. is concluded synthesis sustained a rate males. Further experiments performed to investigate basis this difference. The effects oophorectomy oestrogen replacement treatment indicate superior reactivity not due presence ovarian tissues. from orchidectomy immunological inferiority partly testes. However, testosterone propionate failed influence response B.P.8 experiments. An acute illness resembling severe `runt disease' observed treated mice after immunization.