Runting Syndromes, Autoimmunity, and Neoplasia

摘要: Publisher Summary This chapter examines the autoimmune or pseudoautoimmune situations and their possible roles in development of neoplasia. The analysis runting is an essential preliminary to a greater understanding original “runt” disease homologous was developed as laboratory model for study immunological mechanisms associated with grafting skin organs acquisition tolerance histoincompatible antigens. situation leading runt originally thought be essentially graft-versus-host reaction (GVHR). However, host responses almost certainly occur. classified potential producers syndromess include (1) experimental chimcras; (2) thymectomy wasting disease; (3) chemical induction; (4) bacterial infection; (5) sterile vaccines; (6) subcellular fractions; (7) viruses. Two other experimentally induced leukopenia reactions within New Zealand black (NZB) strain mice. chimeras are further subdivided into parabiotic intoxication, radiation chimeras, parental F1 hybrid situation. induction true yet verified. It may that extensive damage host's immunity system both encourages allows aberrant clone cells develop mount immune response directed against host. Of seven presented this only two (bacterial infection vaccines) present no immediate evidence involvement. Further remaining five syndromes indicates direction permanent animal.