Hepatitis C virus: an overview of current approaches and progress.

摘要: Hepatitis C virus (HCV) was unambiguously identified in the year 1989 as agent responsible for most cases of non-A, non-B hepatitis, a chronic disease that often leads to cirrhosis and hepatocellular carcinoma. Having developed means detect general population, it is now apparent HCV infection widespread likely remain health threat unless effective treatments are developed. The inability propagate tissue culture scarcity convenient animal models have proved be major obstacles drug discovery. Despite these limitations, several opportunities exist targeted development based on viral enzymes been characterized so far. These targets inhibitors reported active against them discussed following review.