Fully automated sample handling system for liquid chromatography based on pre-column technology and automated cartridge exchange.

作者: M.W.F. Nielen , A.J. Valk , R.W. Frei , U.A.Th. Brinkman , Ph. Mussche

DOI: 10.1016/S0021-9673(01)94205-0

关键词:

摘要: The design of an automated cartridge exchange module for on-line sample handling in liquid chromatography is described. When combined with a low-cost purge pump, solvent selection valve and auto-sampler, fully system obtained. Samples are sorbed on disposable packed 40 μm octyl-bonded silica, purged clean-up eluted to the analytical column. Unattended operation demonstrated various examples, i.e., determination anti-epileptic drugs serum, anti-cancer drug plasma, barbiturates urine, phenylurea herbicides river water caffeine soft drink.

参考文章(15)
M.W.F. Nielen, R.W. Frei, U.A.Th. Brinkman, Use of cation exchangers for the on-line preconcentration of polar anilines in liquid chromatography Journal of Chromatography A. ,vol. 317, pp. 557- 567 ,(1984) , 10.1016/S0021-9673(01)91696-6
J.C. Pearce, J.A. Jelly, K.A. Fernandes, W.J. Leavens, R.D. McDowall, Analysis of 5-(4-acetamidophenyl)pyrazin-2(1H)-one (SK&F 94120) in plasma with an analytichem automated sample processor liquid chromatography module Journal of Chromatography A. ,vol. 353, pp. 371- 378 ,(1986) , 10.1016/S0021-9673(01)87107-7
Uwe Juergens, Pre-column switching techniques for the determination of drugs and metabolites in body fluids in research and routine analysis International Journal of Environmental Analytical Chemistry. ,vol. 25, pp. 221- 233 ,(1986) , 10.1080/03067318608077090
M. W. F. Nielen, E. Sol, R. W. Frei, U. A. Th. Brinkman, A Miniaturized Precolumn for On-Line Trace Enrichment and Direct Plasma Injection in Narrow-Bore Liquid Chromatography Journal of Liquid Chromatography & Related Technologies. ,vol. 8, pp. 1053- 1070 ,(1985) , 10.1080/01483918508067128
C.E. Goewie, M.W.F. Nielen, R.W. Frei, U.A.Th. Brinkman, Optimization of precolumn design in liquid chromatography Journal of Chromatography A. ,vol. 301, pp. 325- 334 ,(1984) , 10.1016/S0021-9673(01)89207-4
R.D. McDowall, J.C. Pearce, G.S. Murkitt, Liquid-solid sample preparation in drug analysis. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 4, pp. 3- 21 ,(1986) , 10.1016/0731-7085(86)80018-8
Reed C. Williams, The use of the PREPTM system for handling of body fluids International Journal of Environmental Analytical Chemistry. ,vol. 18, pp. 37- 49 ,(1984) , 10.1080/03067318408076990
R. W. Frei, M. W. F. Nielen, U. A.Th. Brinkman, Handling of Environmental and Biological Samples via Pre-Column Technologies International Journal of Environmental Analytical Chemistry. ,vol. 25, pp. 3- 35 ,(1986) , 10.1080/03067318608077075
M. W. F. Nielen, J. De Jong, R. W. Frei, U. A.Th. Brinkman, Trace-Level Determination of Phenol by Liquid Chromatography with On-Line Precolumn Technology and Fluorescence Detection International Journal of Environmental Analytical Chemistry. ,vol. 25, pp. 37- 48 ,(1986) , 10.1080/03067318608077076