Inhaled high molecular weight hyaluronan ameliorates respiratory failure in acute COPD exacerbation: a pilot study.

摘要: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) carry significant morbidity and mortality. AECOPD treatment remains limited. High molecular weight hyaluronan (HMW-HA) is a glycosaminoglycan sugar, which physiological constituent the lung extracellular matrix has notable anti-inflammatory hydrating properties. We hypothesized that inhaled HMW-HA will improve outcomes in AECOPD. conducted single center, randomized, placebo-controlled, double-blind study to investigate effect patients with severe necessitating non-invasive positive-pressure ventilation (NIPPV). Primary endpoint was time until liberation from NIPPV. Out 44 screened patients, 41 were included (21 for placebo 20 HMW-HA). Patients treated had significantly shorter duration also lower measured peak airway pressures on ventilator systemic inflammation markers after In vitro testing showed improved mucociliary transport air–liquid interface cultures primary bronchial cells COPD healthy exposed cigarette smoke extract. Inhaled shortens respiratory failure need Beneficial effects clearance may account some (NCT02674880, www.clinicaltrials.gov ).