FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas.

摘要: Different cell types interpret their distinct extracellular matrix (ECM) environments to bring about specific fate decisions, and can differentiate or undergo apoptosis depending on local adhesive interactions. Apoptosis in response an inappropriate ECM environment is termed `anoikis', homelessness. Several studies, utilising a variety of types, have indicated common, crucial role for focal adhesion kinase (FAK) suppressing anoikis. A wide range different integrins activate FAK, raising the question how type effects are regulated. In this study, we used constitutively active form FAK examine mechanism FAK-mediated survival signalling from embryonic lineages that show differing sensitivities We demonstrate both fibroblasts epithelial cells prevent anoikis through activation. activates multiple downstream pathways order suppress However regulates more restricted set anoikis-sensitive cells. Furthermore, identify novel paxillin suppression.