Evaluation of the plasmatic and parenchymal elution kinetics of two different irinotecan-loaded drug-eluting embolics in a pig model.

摘要: Abstract Purpose To evaluate and compare irinotecan elution kinetics of two drug-eluting embolic agents in a porcine model. Materials Methods Embolization the left liver lobe was performed 16 domestic pigs, with groups receiving 1 mL DC Bead M1 (70–150 µm) or Embozene TANDEM (75 loaded 50 mg irinotecan. Irinotecan plasma levels were measured at 0, 10, 20, 30, 60, 120, 180, 240 minutes after completed embolization time euthanasia (24 h, 48 72 7 d). Liver tissue samples taken to measure concentrations. Results The highest concentrations both 10 20 embolization, significantly higher for versus ( P = .0019 .0379, respectively). At hours later follow-up, no measurable plasma. For agents, concentration found 24 decreased time-dependent manner follow-up intervals. Additionally, SN-38 therapeutic hours, one embolized particles. Histopathologic analysis revealed ischemic, inflammatory, fibrotic reactions. Conclusions is hepatic types irinotecan-eluting agents. shows early burst kinetics, whereas has lower slower release profile. initial greater than TANDEM.