Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus
作者： Elizabeth L Bird-Lieberman , André A Neves , Pierre Lao-Sirieix , Maria O'Donovan , Marco Novelli
DOI: 10.1038/NM.2616
关键词:
摘要: Barrett's esophagus is an example of a pre-invasive state, for which current endoscopic surveillance methods to detect dysplasia are time consuming and inadequate. The prognosis cancer arising in improved by early detection at the stage mucosal carcinoma or high-grade dysplasia. Molecular imaging could revolutionize dysplasia, provided they permit wide field view highlight abnormalities real time. We show here that cell-surface glycans altered progression from adenocarcinoma lead specific changes lectin binding patterns. chose wheat germ agglutinin as candidate with clinical potential. human tissue was determined be specific, we validated this successful visualization dysplastic lesions, were not detectable conventional endoscopy, high signal-to-background ratio over 5.
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