Time trends in incidence of cutaneous melanoma by detailed anatomical location and patterns of ultraviolet radiation exposure: a retrospective population-based study.

摘要: Given the wide public health implications of melanoma epidemic, ultraviolet radiation (UVR) exposure patterns contributing to cutaneous development should be clearly identified. To describe time trends anatomic sites using a UVR model based on clothing and sun habits, we reviewed medical records all patients diagnosed with primary invasive or in situ (MIS) during years 1977-78, 1983-84, 1989-90, 1995-96, 2000-01 (n=3058) one healthcare region Sweden. Age-standardized incidence rates relative risks (RRs) by calendar period were estimated for intermittent chronic sites. From 1977-78 2000-01, melanomas at increased both among men (7.8-16.5/10 person-years) women (7.6-14.6/10 person-years), sex-adjusted age-adjusted RR 2.1 [95% confidence interval (CI) 1.8-2.4, Ptrend<0.0001]. This increase was evident MIS. Melanoma from 1.7 2.3/10 person-years, 1.4 1.8/10 corresponding adjusted (95% CI 1.0-1.9, Ptrend=0.01), driven primarily For sites, male sex positively associated central (core) areas (chest, back, neck, shoulders, thighs; 1.7, 95% 1.5-1.9), but negatively peripheral (lateral arms, lower legs, dorsum feet; 0.3, 0.3-0.4), compared female sex. Sex-specific drove observed incidence, whereas contributed less.