Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
作者： Steven E. Shoelson , Silvio Inzucchi , Adam B. Mayerson , Gerald I. Shulman , Ripudaman S. Hundal
DOI: 10.1172/JCI14955
关键词:
摘要: … While early studies suggested a salutary effect of aspirin on glucose metabolism in … type 2 diabetes. We measured basal and insulin-stimulated rates of whole-body glucose metabolism …
dm5migu4zj3pb.cloudfront.net 参考文章(27)
J. Reid, T. D. Lightbody, Insulin Equivalence of Salicylate BMJ. ,vol. 1, pp. 897- 900 ,(1959) , 10.1136/BMJ.1.5126.897
Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor, The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β Nature. ,vol. 396, pp. 77- 80 ,(1998) , 10.1038/23948
Hans Ulrich Bergmeyer, Methods of Enzymatic Analysis ,(1963)
G I Shulman, G Cline, W C Schumann, V Chandramouli, K Kumaran, B R Landau, Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans American Journal of Physiology-endocrinology and Metabolism. ,vol. 259, ,(1990) , 10.1152/AJPENDO.1990.259.3.E335
WILLIAM P. NEWMAN, ROBERT G. BRODOWS, Aspirin Causes Tissue Insensitivity to Insulin In Normal Man The Journal of Clinical Endocrinology and Metabolism. ,vol. 57, pp. 1102- 1106 ,(1983) , 10.1210/JCEM-57-6-1102
J. Reid, A. I. Macdougall, M. M. Andrews, Aspirin and Diabetes Mellitus BMJ. ,vol. 2, pp. 1071- 1074 ,(1957) , 10.1136/BMJ.2.5053.1071
M. Yuan, Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkbeta Science. ,vol. 293, pp. 1673- 1677 ,(2001) , 10.1126/SCIENCE.1061620
M. E. Griffin, M. J. Marcucci, G. W. Cline, K. Bell, N. Barucci, D. Lee, L. J. Goodyear, E. W. Kraegen, M. F. White, G. I. Shulman, Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. ,vol. 48, pp. 1270- 1274 ,(1999) , 10.2337/DIABETES.48.6.1270
Kathryn De Fea, Richard A. Roth, Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. Biochemistry. ,vol. 36, pp. 12939- 12947 ,(1997) , 10.1021/BI971157F
R. T. Williamson, On the Treatment of Glycosuria and Diabetes Mellitus with Sodium Salicylate BMJ. ,vol. 1, pp. 760- 762 ,(1901) , 10.1136/BMJ.1.2100.760