Specific neurotoxicity of chronic use of ecstasy.
作者： J Obrocki , A Schmoldt , R Buchert , B Andresen , K Petersen
DOI: 10.1016/S0378-4274(01)00511-2
关键词:
摘要: The use of the illicit drug ecstasy (mainly containing methylenedioxymethamphetamine, MDMA) is widespread among young people in western Nations. Animal experiments indicate that MDMA a potent neurotoxin specifically affecting serotonergic system. A few functional neuroimaging studies revealed central nervous alterations after repeated ecstasy. We examined 94 users comparison to 27 control subjects by means positron emission tomography (PET) with 2-[18F]-fluoro-2-deoxy-D-glucose (FDG). FDG uptake rates were globally reduced users, most pronounced striatum. tended be negatively correlated cumulative doses. results younger may more vulnerable regard neurotoxicity.
elsevier.com
maps.org 参考文章(85)
N Wodarz, J Böning, ["Ecstasy"-induced psychotic depersonalization syndrome]. Nervenarzt. ,vol. 64, pp. 478- 480 ,(1993)
R. Thomasius, M. Schmolke, D. Kraus, [MDMA ("Ecstasy") use--an overview of psychiatric and medical sequelae]. Fortschritte Der Neurologie Psychiatrie. ,vol. 65, pp. 49- 61 ,(1997) , 10.1055/S-2007-996309
E O'Hearn, G Battaglia, EB De Souza, MJ Kuhar, ME Molliver, Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity The Journal of Neuroscience. ,vol. 8, pp. 2788- 2803 ,(1988) , 10.1523/JNEUROSCI.08-08-02788.1988
J E Sprague, D E Nichols, The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits. Journal of Pharmacology and Experimental Therapeutics. ,vol. 273, pp. 667- 673 ,(1995)
H. S. Fischer, G. Zernig, D. S. Schatz, C. Humpel, A. Saria, MDMA (‘ecstasy’) enhances basal acetylcholine release in brain slices of the rat striatum European Journal of Neuroscience. ,vol. 12, pp. 1385- 1390 ,(2000) , 10.1046/J.1460-9568.2000.00004.X
G A Ricaurte, J L Katz, A L Martello, M B Martello, Lasting effects of (+-)-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: neurochemical observations. Journal of Pharmacology and Experimental Therapeutics. ,vol. 261, pp. 616- 622 ,(1992)
C J Schmidt, Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. Journal of Pharmacology and Experimental Therapeutics. ,vol. 240, pp. 1- 7 ,(1987)
Gilberto Gerra, Amir Zaimovic, Mila Ferri, Ursula Zambelli, Mariaemanuela Timpano, Elisabetta Neri, Gian Franco Marzocchi, Roberto Delsignore, Francesca Brambilla, Long-lasting effects of (±)3,4-methylene-dioxymethamphetamine (Ecstasy) on serotonin system function in humans Biological Psychiatry. ,vol. 47, pp. 127- 136 ,(2000) , 10.1016/S0006-3223(99)00180-8
Vicki L. Taylor, Christopher J. Schmidt, Christine K. Black, Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine. European Journal of Pharmacology. ,vol. 181, pp. 59- 70 ,(1990) , 10.1016/0014-2999(90)90245-2
H. Remschmidt, Ecstasy - Eine Studie zu gesundheitlichen und psychosozialen Folgen des Missbrauchs Zeitschrift Fur Kinder-und Jugendpsychiatrie Und Psychotherapie. ,vol. 29, pp. 325- 326 ,(2001) , 10.1024//1422-4917.29.4.325