Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood.

摘要: Pre-exposure to psychostimulants enhances the rewarding and psychomotor stimulating effects of subsequent drug exposure. Currently, there is a prevalence adolescent exposure methylphenidate (MPD) 3,4-methylenedioxymethamphetamine (MDMA). However, paucity investigation concerning long-term behavioral consequences these stimulants during adolescence. The aim present study was investigate effect MPD MDMA in adolescence on cocaine-induced reward stimulation adulthood. Adolescent Swiss-Webster mice received intraperitoneal injections saline, (10 mg/kg) or from PD 26 32. Animal weights were monitored after administration. One month later, conditioned place preference (CPP) locomotor activity (LMA) investigated. inhibited weight increase 28 39 compared saline group, but amongst three groups equalized by 46. resulted same magnitude cocaine (20 mg/kg)-induced CPP as exposure; however, caused significantly less CPP. Two weeks following extinction withdrawal cocaine, priming injection (5 reinstated higher than group. In LMA experiments, (15 administered for 5 consecutive days. On days 1 5, hyperlocomotion group groups. After 2-week period, evoked responses Results suggest that both involves long-lasting neural adaptations, manifested sensitized withdrawal.