Tricarbonyl (99m)Tc(i) and Re(i)-thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection.
作者： Dipak Kumar Nayak , Rinku Baishya , Ramalingam Natarajan , Tuhinadri Sen , Mita Chatterjee Debnath
DOI: 10.1039/C5DT02264A
关键词:
摘要: Methyl, ethyl and phenyl nitrofuryl thiosemicarbazone ligands (, respectively) were radiolabeled with freshly prepared aqueous solution of a fac[(99m)Tc(CO)3(H2O)3](+) precursor. The radiochemical yield was around 98% as determined by thin layer chromatography HPLC. complexes exhibited substantial stability. corresponding Re(i) from Re(CO)5Br precursor to understand the coordination behavior against tricarbonyl rhenium(i) characterized means IR, NMR mass spectroscopic studies well X-ray crystallography, correlated technetium HPLC studies. Electrochemical reduction monomeric Re(CO)3-complexes also studied using cyclic voltammetry. Biodistribution (99m)Tc(CO)3-labeled thiosemicarbazones in rats intramuscularly infected S. aureus vivo stability complex moderate accumulation at site focal infection.
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