GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis
作者： Kentaro Toyoda , Teru Okitsu , Shunsuke Yamane , Taeko Uonaga , Xibao Liu
DOI: 10.1016/J.BBRC.2008.01.046
关键词:
摘要: To clarify the cytoprotective effect of glucagon-like peptide-1 receptor (GLP-1R) signaling in conditions glucose toxicity vivo, we performed murine isogenic islet transplantation with and without exendin-4 treatment. When a suboptimal number islets (150) were transplanted into streptozotocin-induced diabetic mice, treatment contributed to restoration normoglycemia. 50 expressing enhanced green fluorescent protein (EGFP) transplanted, reversed loss both mass grafts one 3 days after transplantation. TUNEL staining revealed that reduced apoptotic beta cells during early posttransplant phase, indicating GLP-1R exerts its on pancreatic by inhibiting their apoptosis. This beneficial might be used ameliorate type 2 diabetes improve engraftment rates clinical
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sci-hub.se 参考文章(28)
J. B. Buse, R. R. Henry, J. Han, D. D. Kim, M. S. Fineman, A. D. Baron, , Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in Sulfonylurea-Treated Patients With Type 2 Diabetes Diabetes Care. ,vol. 27, pp. 2628- 2635 ,(2004) , 10.2337/DIACARE.27.11.2628
Masaru Okabe, Masahito Ikawa, Katsuya Kominami, Tomoko Nakanishi, Yoshitake Nishimune, Green mice' as a source of ubiquitous green cells FEBS Letters. ,vol. 407, pp. 313- 319 ,(1997) , 10.1016/S0014-5793(97)00313-X
P. L. Brubaker, D. J. Drucker, Minireview: Glucagon-Like Peptides Regulate Cell Proliferation and Apoptosis in the Pancreas, Gut, and Central Nervous System Endocrinology. ,vol. 145, pp. 2653- 2659 ,(2004) , 10.1210/EN.2004-0015
Yukihide Yonekawa, Teru Okitsu, Kenjiro Wake, Yasuhiro Iwanaga, Hirofumi Noguchi, Hideo Nagata, Xiaoling Liu, Naoya Kobayashi, Shinichi Matsumoto, A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft site. Transplantation. ,vol. 82, pp. 712- 715 ,(2006) , 10.1097/01.TP.0000234906.29193.A6
Bernardo Yusta, Laurie L. Baggio, Jennifer L. Estall, Jackie A. Koehler, Dianne P. Holland, Hongyun Li, Danny Pipeleers, Zhidong Ling, Daniel J. Drucker, GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress Cell Metabolism. ,vol. 4, pp. 391- 406 ,(2006) , 10.1016/J.CMET.2006.10.001
Daniel J. Drucker, The biology of incretin hormones Cell Metabolism. ,vol. 3, pp. 153- 165 ,(2006) , 10.1016/J.CMET.2006.01.004
Khalid Al Ghofaili, Michelle Fung, Ziliang Ao, Mark Meloche, R Jean Shapiro, Garth L. Warnock, Dariush Elahi, Graydon S. Meneilly, David M. Thompson, Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes. Transplantation. ,vol. 83, pp. 24- 28 ,(2007) , 10.1097/01.TP.0000251379.46596.2D
A. King, J. Lock, G. Xu, S. Bonner-Weir, G. C. Weir, Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment Diabetologia. ,vol. 48, pp. 2074- 2079 ,(2005) , 10.1007/S00125-005-1922-0
A. A. Young, B. R. Gedulin, S. Bhavsar, N. Bodkin, C. Jodka, B. Hansen, M. Denaro, Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes. ,vol. 48, pp. 1026- 1034 ,(1999) , 10.2337/DIABETES.48.5.1026
Teru Okitsu, Stephen T. Bartlett, Gregg A. Hadley, Cinthia B. Drachenberg, Alan C. Farney, Recurrent autoimmunity accelerates destruction of minor and major histoincompatible islet grafts in nonobese diabetic (NOD) mice. American Journal of Transplantation. ,vol. 1, pp. 138- 145 ,(2001) , 10.1034/J.1600-6143.2001.10207.X