A new mouse model for intraportal islet transplantation with limited hepatic lobe as a graft site.
作者： Yukihide Yonekawa , Teru Okitsu , Kenjiro Wake , Yasuhiro Iwanaga , Hirofumi Noguchi
DOI: 10.1097/01.TP.0000234906.29193.A6
关键词:
摘要: Intraportal site is the standard for grafting in clinical islet transplantation. In mouse model, whole liver has been used as to mimic However, this model lacks potency directly assess contribution of graft diabetes control. Only demonstrating immediate recurrence a surviving recipient after removal can validate assessment. study, we develop intraportal transplantation equipped with assessment by injecting islets selectively into right hepatic lobe under temporal clamp left portal vein. The survives hepatectomy which removed. This be applied investigate both specific graft-recipient interaction and control diabetes.
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