Natural Anti-Self Reactivity Which Maps to MHC Class I Genes

摘要: Responder spleen cells of [B10.A(5R) x B10.A(2R)]F1 hybrid mice cultured in vitro with irradiated parental cells, generate a cytotoxic T cell response which maps to the H-2Dd and H-2(K-I)b genes B10.A(5R) parent. Specific reactivity (5R 2R) (P) stimulators not F1 or B10.A(2R) was also demonstrated as an anti-P proliferative response. Generation anti-5R has been noted during 2 degrees anti-viral responses where from either ectromelia Sendai virus primed have stimulated infected 5R but when 2R cells. The generation these is dependent on use for culture. All data consistent hypothesis that are tolerant 4-fold higher level Class I H-2Kb/Dd antigens they express.