Toxicity effects of compressed and supercritical solvents on thermophilic microbial metabolism
作者： Jason A. Berberich , Barbara L. Knutson , Herbert J. Strobel , Sefa Tarhan , Sue E. Nokes
DOI: 10.1002/1097-0290(20001205)70:5<491::AID-BIT3>3.0.CO;2-U
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摘要: Selection of biocompatible solvents is critical when designing bioprocessing applications for the in situ biphasic extraction metabolic end-products. The prediction biocompatibility supercritical and compressed more complicated than liquid solvents, because their properties can change significantly with pressure temperature. activity anaerobic thermophilic bacterium, Clostridium thermocellum, was studied organism incubated presence nitrogen, ethane, propane at 333 K multiple pressures. organisms contact analyzed using traditional indicators solvent biocompatibility, such as log P, interfacial tension, density. toxicity compared phase molecular effects measured alkanes atmospheric pressure. Inactivation increased time but constant solvents. Knowledge provides a framework interpretation C. thermocellum metabolism
sci-hub.se 参考文章(30)
G. Wienke, J. Gmehling, Prediction of octanol‐water partition coefficients, Henry coefficients and water solubilities using UNIFAC Toxicological & Environmental Chemistry. ,vol. 65, pp. 57- 86 ,(1998) , 10.1080/02772249809358557
H.P. Gros, S.B. Bottini, E.A. Brignole, High pressure phase equilibrium modeling of mixtures containing associating compounds and gases Fluid Phase Equilibria. ,vol. 139, pp. 75- 87 ,(1997) , 10.1016/S0378-3812(97)00099-X
H.P. Gros, S. Bottini, E.A. Brignole, A group contribution equation of state for associating mixtures Fluid Phase Equilibria. ,vol. 116, pp. 537- 544 ,(1996) , 10.1016/0378-3812(95)02928-1
S.I. Sandler, Infinite dilution activity coefficients in chemical, environmental and biochemical engineering Fluid Phase Equilibria. ,vol. 116, pp. 343- 353 ,(1996) , 10.1016/0378-3812(95)02905-2
Esteban A. Brignole, Poul M. Andersen, Aage Fredenslund, Supercritical fluid extraction of alcohols from water Industrial & Engineering Chemistry Research. ,vol. 26, pp. 254- 261 ,(1987) , 10.1021/IE00062A013
Richard K. Owusu, Donald A. Cowan, Correlation between microbial protein thermostability and resistance to denaturation in aqueous: organic solvent two-phase systems Enzyme and Microbial Technology. ,vol. 11, pp. 568- 574 ,(1989) , 10.1016/0141-0229(89)90084-7
Joan F. Brennecke, Charles A. Eckert, Phase equilibria for supercritical fluid process design Aiche Journal. ,vol. 35, pp. 1409- 1427 ,(1989) , 10.1002/AIC.690350902
A Isenschmid, The influence of pressure and temperature of compressed CO2 on the survival of yeast cells Journal of Biotechnology. ,vol. 39, pp. 229- 237 ,(1995) , 10.1016/0168-1656(95)00018-L
James B. Russell, R. L. Baldwin, Substrate preferences in rumen bacteria: evidence of catabolite regulatory mechanisms. Applied and Environmental Microbiology. ,vol. 36, pp. 319- 329 ,(1978) , 10.1128/AEM.36.2.319-329.1978
B.L Knutson, H.J Strobel, S.E Nokes, K.A Dawson, J.A Berberich, C.R Jones, Effect of pressurized solvents on ethanol production by the thermophilic bacterium Clostridium thermocellum The Journal of Supercritical Fluids. ,vol. 16, pp. 149- 156 ,(1999) , 10.1016/S0896-8446(99)00026-1