Motor unit changes in sporadic idiopathic Parkinson's disease.

摘要: We studied motor unit changes in 20 patients with Parkinson's disease (PD) and age-matched control subjects to look for evidence of motorneuron degeneration sporadic idiopathic PD. Patients were screened by clinical criteria nerve conduction studies exclude those peripheral neuropathic processes. Changes morphology investigated subjective computerized quantitative electromyography (QEMG) the anterior tibialis (AT) first dorsal interosseous. Multivariate comparisons showed a significant difference QEMG analysis enlargement PD versus subjects. Some univariate both analyses AT also significant. These results demonstrate that drop-out reinnervation occurs In summary, our findings provide clinically silent typical cases PD, suggesting it may be normal part pathologic picture Any hypothesis concerning pathogenic mechanism would need take into account such finding.