Ultrastructural study of skein-like inclusions in anterior horn neurons of patients with motor neuron disease
作者： Shoichi Sasaki , Shoichi Maruyama
DOI: 10.1016/0304-3940(92)90575-R
关键词: Lewy body 、 Skein-like inclusion 、 Hyaline inclusion 、 Vesicle 、 Anatomy 、 Lewy body-like hyaline inclusion 、 Motor neuron 、 Protein filament 、 Ultrastructure 、 Biophysics 、 Chemistry 、 General Neuroscience
摘要: Abstract We investigated the ultrastructure of skein-like inclusions (SI) in 11 patients with motor neuron disease. SI mainly consisted bundles filaments. Each filament was approximately 15–25 nm diameter and had a tubular profile on transverse sections. occasionally appeared to contain electron-dense material similar Bunina bodies (BB), clusters SI, closely resembling BB vesicles were scattered among filaments or directly attached filaments, suggesting close relationship between BB. also infer that might be precursor Lewy body-like hyaline (LBHI), basis frequent presence in-between structures, coexistence LBHI, detection profiles (component SI) far greater frequency which observed compared occasional connection ubiquitin-positive LBHI preceding immunocytochemical studies.
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