Characterizations of heterotopic neurons in the spinal cord of amyotrophic lateral sclerosis patients.

摘要: This report concerns a comparative immunocytochemical, ultrastructural and morphometric investigation on heterotopic neurons in the white matter of spinal cords 19 patients with amyotrophic lateral sclerosis (ALS) 18 age-matched neurologically normal individuals. The study revealed that were scattered matter, often adjacent to gray they immunoreacted antibody synaptophysin, there synaptic apparatuses surface their somata neuronal processes. Bunina bodies ubiquitin-positive inclusions such as Lewy body-like skein-like inclusions, characteristic anterior horn ALS, present cytoplasm patients' or column matter. These findings suggest have characteristics alpha motor neurons. average number observed ALS was generally less than subjects. reduction correlated severity loss. susceptible degenerative process compared cord cells. We assume this disease may be degenerated diminished after concomitantly depletion