Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro
作者： Sudha Ponnusamy , Remya Ravindran , Smita Zinjarde , Shobha Bhargava , Ameeta Ravi Kumar
DOI: 10.1155/2011/515647
关键词:
摘要: Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control starch breakdown. Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected sequential solvent extraction and tested for inhibition, in order assess evaluate their inhibitory potential on pancreatic α-amylase. Analysis 91 extracts, showed that 10 exhibited strong Human Amylase (HPA) potential. Of these, 6 extracts concentration dependent inhibition IC50 values, namely, cold hot water from Ficus bengalensis bark (4.4 125 μgmL-1), Syzygium cumini seeds (42.1 4.1 isopropanol Cinnamomum verum leaves (1.0 μgmL-1) Curcuma longa rhizome (0.16 μgmL-1). The other 4 independent methanol extract Bixa orellana (49 Murraya koenigii (127 acetone C. (7.4 Tribulus terrestris (511 Thus, probable mechanism action above fractions is due HPA, thereby reducing rate hydrolysis leading lowered glucose levels. Phytochemical analysis revealed presence alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins steroids as compounds.
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