Higher potency statins and the risk of new diabetes: multicentre, observational study of administrative databases

摘要: Objective To evaluate the incremental increase in new onset diabetes from higher potency statins compared with lower when used for secondary prevention. Design Eight population based cohort studies and a meta-analysis. Setting Six Canadian provinces two international databases UK US. Participants 136 966 patients aged ≥40 years newly treated between 1 January 1997 31 March 2011. Methods Within each of prescribed statin after hospitalisation major cardiovascular event or procedure, we performed as-treated, nested case-control analyses to compare incidence users statins. Rate ratios events were estimated using conditional logistic regression on different lengths exposure versus statins; adjustment confounding was achieved high dimensional propensity scores. Meta-analytic methods estimate overall effects across sites. Main outcome measures Hospitalisation diabetes, prescription insulin an oral antidiabetic drug. Results In first regular use, observed significant risk agents (rate ratio 1.15, 95% confidence interval 1.05 1.26). The seemed be highest four months use 1.26, 1.07 1.47). Conclusions Higher is associated moderate prevention disease. Clinicians should consider this prescribing patients.