Histopathological study of experimental poststreptococcal pneumonia in mice. Group A, type 50, streptococcal infection of murine nares controls with Staphylococcus aureus and E. coli.

摘要: Summary Microscopic methods (light and electron microscopy, histochemistry, immunohistochemistry) have been used to assess previously unknown pulmonary inflammatory responses of specific pathogen-free (SPF) mice secondary infection via the nares by group A, type 50, streptococci suspended in saline (“strep mice”). As controls for strep mice, animals were either injected with alone (no lesions seen), or Staphylococcus aureus (“staph mice”) E. coli (“E. The three different bacterial species caused clearly histological changes lung. In microscopic findings consistent diagnosis lymphocytic interstitial pneumonia bronchiolovascular bundles, exaggerated recirculation lymphocytes, concomitant vasoconstrictive angiopathy encased artery branches nodular cell aggregates lung parenchyma. These consisted predominantly mixed cells (neutrophils, macrophages) activated macrophages only. 18 22 inflamed lungs no bacteria could be cultured from tissue. staph are lymphocytes 12 17 distal terminal bronchiolitis early pleural-based pneumonitis, which neutrophils mingled macrophages. 10 11 morphologic approaches described here may potential unravelling complex processes underlying forms parenchymal pneumoma.