The WHO Review of the Possible Nonspecific Effects of Diphtheria-Tetanus-Pertussis Vaccine.

摘要: Background World Health Organization recently reviewed the possible nonspecific effects of diphtheria-tetanus-pertussis (DTP) vaccine. The results were considered inconsistent though most studies suggested deleterious effects. We examined whether inconsistencies in reflected differences effect DTP or methodology used different studies. Methods If children remain unvaccinated because they are frail if (including dead ones) with no information on vaccination status classified as "unvaccinated," mortality rate becomes unnaturally high among "unvaccinated" controls. To measure this bias, we defined "bias index" ratio (MRR) between and vaccinated children. Results Five had poorly control groups survival bias index being 2.0-8.0; these was associated an MRR 0.39 (0.18-0.83). Eight determined by card 0.5-1.7; 2.00 (1.50-2.67). Conclusion observed methodologic Bias does not seem to explain why is higher mortality.