Agmatine improves renal function in gentamicin-induced nephrotoxicity in rats.
作者： Dalia H. El-Kashef , Asmaa E. El-Kenawi , Mona Abdel Rahim , Ghada M. Suddek , Hatem A. Salem
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摘要: The present study was designed to explore the possible protective effects of agmatine, a known nitric oxide (NO) synthase inhibitor, against gentamicin-induced nephrotoxicity in rats. For this purpose, we quantitatively evaluated renal structural and functional alterations using histopathological biochemical approaches. Furthermore, effect agmatine on hypersensitivity urinary bladder rings acetylcholine (ACh) evaluated. Twenty-four male Wistar albino rats were randomly divided into 3 groups, namely control, gentamicin (100 mg/kg, i.p.), plus (40 orally). At end study, all sacrificed then blood urine samples kidneys taken. Administration significantly decreased kidney/body mass ratio, serum creatinine, lactate dehydrogenase (LDH), malondialdehyde (MDA), myeloperoxidase (MPO), NO, tumor necrosis factor-alpha (TNF-α) while it increased creatinine clearance superoxide dismutase (SOD) activity when compared with gentamicin-treated group. Additionally, ameliorated tissue morphology as evidenced by histological evaluation reduced responses isolated ACh. Our indicates that administration attenuates oxidative-stress associated injury reducing oxygen free radicals lipid peroxidation, restoring NO level inhibiting inflammatory mediators such TNF-α.
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