Signal transduction by the receptor tyrosine kinase Ret.
作者： D. H. J. van Weering , J. L. Bos
DOI: 10.1007/978-3-642-46870-4_18
关键词:
摘要: Ret is the receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN). Defects in this underlie several genetic syndromes. The a transmembrane tyrosine kinase which transduces Ret-mediated signaling to variety of pathways, most notably Ras pathway phosphatidylinositol-3 pathway. These pathways are activated through interaction adaptor proteins phosphorylated receptor. ultimate biological effects, depending on type, include morphological changes cytoskeleton, scattering, proliferation, differentiation.
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