three waves of distinct chemokines to recruit immune effectors Upon viral exposure myeloid and plasmacytoid dendritic cells produce

摘要: Summary Host response to viral infection involves distinct effectors of innate and adaptive immunity, whose mobilization needs be coordinated insure protection. Here we show that Influenza virus triggers in human blood dendritic cell (DC) subsets, i.e., plasmacytoid myeloid DCs, a chemokine (CK) secretion program with three successive waves. The first one, occurring at early time points (2-4 hours), includes CKs potentially attracting effector cells like neutrophils, cytotoxic T NK (CXCL16, CXCL1, CXCL2, CXCL3). second one occurs within 8 12 hours memory (CXCL8, CCL3, CCL4, CCL5, CXCL9, CXCL10, CXCL11). third wave, which after 24-48 hours, when DCs have reached the lymphoid organs, CCL19, CCL22 CXCL13, attract naive B lymphocytes. Thus, DC subsets carry common CK production, allow for attraction different immune infection. From bloodjournal.hematologylibrary.org by guest on June 5, 2013. For personal use only.