The neural correlates of fatigue: an exploratory imaginal fatigue provocation study in chronic fatigue syndrome.

摘要: Background. Fatigue is the central symptom in chronic fatigue syndrome (CFS) and yet very little known about its neural correlates. The aim of this study was to explore functional brain response, using magnetic resonance imaging (fMRI), imaginal experience CFS patients controls. Method. We compared blood oxygen level dependent (BOLD) responses 12 11 healthy controls a novel provocation procedure designed mimic real-life situations. A non-fatiguing anxiety-provoking condition also included control for non-specific effects negative affect. Results. During fatigue, reported feelings both anxiety and, controls, they showed increased activation occipito-parietal cortex, posterior cingulate gyrus parahippocampal gyrus, decreased dorsolateral dorsomedial prefrontal cortices. reverse pattern findings observed during scenarios. Conclusions. The results may suggest that, patients, associated with exaggerated emotional that have difficulty suppressing. These are discussed relation cognitive-behavioural model CFS.