Tyrosine Kinase Inhibitors and Diabetes: A Novel Treatment Paradigm?
作者： Athanasios Fountas , Leonidas-Nikolaos Diamantopoulos , Agathocles Tsatsoulis
DOI: 10.1016/J.TEM.2015.09.003
关键词:
摘要: Deregulation of protein tyrosine kinase (PTK) activity is implicated in various proliferative conditions. Multi-target inhibitors (TKIs) are increasingly used for the treatment different malignancies. Recently, several clinical cases reversal both type 1 and 2 diabetes mellitus (T1DM, T2DM) during TKI administration have been reported. Experimental vivo vitro studies elucidated some mechanisms behind this effect. For example, inhibition Abelson (c-Abl) results β cell survival enhanced insulin secretion, while platelet-derived growth factor receptor (PDGFR) epidermal (EGFR) leads to improvement sensitivity. In addition, vascular endothelial (VEGFR2) reduces degree islet inflammation (insulitis). Therefore, targeting PTKs may provide a novel approach correcting pathophysiologic disturbances diabetes.
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