Involvement of oxidative stress in the pathogenesis of diabetes.

摘要: Pancreatic beta-cell failure is the common characteristic of type 1 and 2 diabetes. Type diabetes induced by pancreatic destruction, which mediated an autoimmune mechanism consequent inflammatory process. Various cytokines oxidative stress produced islet-infiltrating immune cells have been proposed to play important role in mediating destruction beta cells. The JNK pathway also activated such involved destruction. most prevalent serious metabolic disease affecting people all over world. dysfunction insulin resistance are hallmark Once hyperglycemia becomes apparent, function gradually deteriorates, aggravated. This process called "glucose toxicity." Under conditions, provoked, activated, likely resistance. In addition, activation progression atherosclerosis, often observed under diabetic conditions. Taken together, it that subsequent pathogenesis