Anticardiolipin and anti‐β2 glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits
作者： T. Avčin , A. Ambrožič , M. Kuhar , T. Kveder , B. Rozman
DOI: 10.1093/RHEUMATOLOGY/40.5.565
关键词:
摘要: OBJECTIVES To determine anticardiolipin (aCL) and anti-beta(2) glycoprotein I antibodies (anti-beta(2)GPI) in apparently healthy children express the cut-off levels concentrations of monoclonal antibodies, to compare mean values frequencies aCL anti-beta(2)GPI with those blood donors. METHODS Blood samples were collected from 29 preschool 32 adolescents during their routine preventive follow-up visits. The control group consisted 52 assayed by an ELISA method. Two beta(2)GPI-dependent (HCAL EY2C9) used as calibrators. RESULTS estimated for immunoglobulin G (IgG) M (IgM) aCL, expressed standardized international units (GPL/MPL units), 13.9 ng/ml (7.6 GPL) 33.1 (3.3 MPL) children, 13.5 (7.2 36.9 (4.0 adolescents, 14.4 (8.0 42.6 (5.1 No statistically significant differences IgG IgM found between age groups. value IgA was significantly higher donors than (P<0.037 P<0.025 respectively). Seven (11.4%) 61 had low positive (IgG all seven). 4.2 13.1 respectively 3.2 2.9 20.5 be (P<0.0001 P<0.0001). (IgM, P<0.007; IgA, P<0.0001) P<0.01; Four (6.6%) (two two IgA). CONCLUSIONS This is first report which are antibodies. Low titres identified frequently hypothesized result previous infections. high observed unexpected study might indicate a default response nutritional exposure beta(2)GPI this group.
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