Association between chronic hemodialysis and bloodstream infections caused by chromosomally mediated AmpC-producing Enterobacteriaceae

摘要: Background The combination of inherent antimicrobial resistance and high mortality after bloodstream infections (BSIs) caused by chromosomally mediated AmpC-producing Enterobacteriaceae (CAE) emphasizes the importance identifying patients at risk BSI because these bacteria. This retrospective case-control study examines chronic hemodialysis among other factors for CAE. Methods Hospitalized adults with from January 1, 2010-June 30, 2014, 2 large community hospitals in Southeastern United States were identified. Multivariate logistic regression was used to examine CAE BSI. Results Among 831 isolates, 106 (13%) met phenotypic definition Enterobacter spp accounted 47% (50/106) BSIs. Chronic an independent factor (adjusted odds ratio [aOR], 2.34; 95% confidence interval [CI], 1.21-4.44). Other predictors included nosocomial acquisition (aOR, 1.72; CI, 1.02-2.87) exposure β-lactam antibiotics within last 30 days 2.39; 1.37-4.14). Conclusions To our knowledge, this is first demonstrate increased end-stage renal disease undergoing hemodialysis. highlights effective infection prevention stewardship interventions clinics. Further studies impact on intestinal microbiota rates colonization patient population are warranted.