Learning Enhances Sensory and Multiple Non-sensory Representations in Primary Visual Cortex.

摘要: We determined how learning modifies neural representations in primary visual cortex (V1) during acquisition of a visually guided behavioral task. imaged the activity same layer 2/3 neuronal populations as mice learned to discriminate two patterns while running through virtual corridor, where one pattern was rewarded. Improvements performance were closely associated with increasingly distinguishable population-level task-relevant stimuli, result stabilization existing and recruitment new neurons selective for these stimuli. These effects correlated appearance multiple task-dependent signals learning: those that increased selectivity across population when expert animals engaged task, reflecting anticipation or choices specifically subsets preferring rewarded stimulus. Therefore, engages diverse mechanisms modify sensory non-sensory V1 adjust its processing task requirements relevance