Role of cytokines in the regulation of reproductive function.

摘要: The levels of 17 cytokines in the follicular fluid were measured by multiplex proteome analysis at peak stimulated ovulation during vitro fertilization cycle. In patients with ineffective folliculogenesis, concentrations IL-2, IL-4, IL-7, and granulocytic CSF significantly lower than women greater mean number collected oocytes. It was shown that multicomponent cytokine deficit associated production high quality oocytes efficiency resultant vitro. absence pregnancy after cycle is CSF, macrophagic inflammatory protein 1b combination elevated contents IL-8 IL-13. results attest to an important role regulation oogenesis preparation endometrium implantation embryo.