Survivin, a Promising Gene for Targeted Cancer Treatment

摘要: Drawbacks of conventional cancer treatments, with lack specificity and cytotoxicity using current approaches, underlies the necessity for development a novel approach, gene-directed therapy. This has provided technological opportunities in vitro vivo. review focuses on member an apoptosis inhibitor family, survivin, as valuable target. Not only gene but also its promoter are applicable this context. article is based literature survey, especial attention to RNA interference well tumor- specific action. The search engine databases utilized were Science direct, PubMed, MEDLINE Google. In addition cell-cycle modulation, inhibition, interaction cell-signaling pathways, cancer-selective expression, survivin may be considered target through treatment cancer. Our purpose writing was create awareness researchers, emphasizing relation expression potential treatment. principal result major conclusion manuscript that structure, biological functions applications systems tumor-specific activity interest