Inhibition of cancer cell proliferation by midazolam by targeting transient receptor potential melastatin 7
作者： YUNLING DOU , YUAN LI , JINGKAO CHEN , SIHAN WU , XIAO XIAO
DOI: 10.3892/OL.2013.1129
关键词:
摘要: Transient receptor potential melastatin 7 (TRPM7), a Ca2+-permeable channel, has been demonstrated to be present in cancer cells and involved their growth proliferation. The study used midazolam, benzodiazepine class anesthesic, pharmacologically intervene the expression of TRPM7 inhibit cell Midazolam significantly inhibited proliferation FaDu human hypopharyngeal squamous carcinoma cells, concurring with induction G0/G1 cycle arrest blockage Rb activation. Central-type peripheral-type antagonists did not abrogate inhibition by while specific agonist bradykinin reversed this effect. In addition, other benzodiazepines, diazepam clonazepam also exhibited anti-proliferative activities. inhibitory activity on proliferation, combined TRPM-dependent mechanism, reveals anticancer midazolam as inhibitor supports suggestion that is valuable target for pharmaceutical intervention.
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