摘要: Cancer is the second most common cause of death in western countries. It therefore fundamental importance to improve treatment patients with malignant tumors. This goal can only be achieved if we get closer insight various mechanisms leading tumor formation. Significant progress understanding carcinogenesis has been made during last couple years. Ion channels contribute regulation cell proliferation which initially shown for K+ channels. Meanwhile, other ion such as Cl-, Na+ and Ca2+ seem influence cellular function like growth, migration invasion. In addition, cation transient receptor potential (TRP) superfamily are implicated cancer Most recent data concerning TRP vanilloid (TRPV) type 6, melastatin (TRPM) 1 8 their relevance human types will highlighted this review. Furthermore, channel structure discussed light possible prognostic markers targets drug discovery.
elsevier.com
sci-hub.se 参考文章(127)
Wei Wu He, Peter J. Sciavolino, John Wing, Meena Augustus, Peter Hudson, P.Scott Meissner, R.Thomas Curtis, Brenda K. Shell, David G. Bostwick, Donald J. Tindall, Edward P. Gelmann, Cory Abate-Shen, Kenneth C. Carter, A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. Genomics. ,vol. 43, pp. 69- 77 ,(1997) , 10.1006/GENO.1997.4715
Arlo J. Miller, Jinyan Du, Sheldon Rowan, Christine L. Hershey, Hans R. Widlund, David E. Fisher, Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Research. ,vol. 64, pp. 509- 516 ,(2004) , 10.1158/0008-5472.CAN-03-2440
Ian D. Meng, David Julius, Sven-Eric Jordt, Diana M. Bautista, Huai-hu Chuang, David D. McKemy, Peter M. Zygmunt, Edward D. Högestätt, Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 Nature. ,vol. 427, pp. 260- 265 ,(2004) , 10.1038/NATURE02282
Monique Paubert-Braquet, Henri Cousse, Jean-Pierre Raynaud, Jean Michel Mencia-Huerta, Pierre Braquet, Effect of the Lipidosterolic Extract of Serenoa repens (Permixon®) and Its Major Components on Basic Fibroblast Growth Factor-Induced Proliferation of Cultures of Human Prostate Biopsies European Urology. ,vol. 33, pp. 340- 347 ,(1998) , 10.1159/000019570
Christian Harteneck, Function and pharmacology of TRPM cation channels Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 371, pp. 307- 314 ,(2005) , 10.1007/S00210-005-1034-X
Huai-hu Chuang, Werner M. Neuhausser, David Julius, The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel Neuron. ,vol. 43, pp. 859- 869 ,(2004) , 10.1016/J.NEURON.2004.08.038
James L. Prescott, Leen Blok, Donald J. Tindall, Isolation and Androgen Regulation of the Human Homeobox cDNA, NKX3.1 The Prostate. ,vol. 35, pp. 71- 80 ,(1998) , 10.1002/(SICI)1097-0045(19980401)35:1<71::AID-PROS10>3.0.CO;2-H
Michael J. Berridge, Calcium signalling and cell proliferation. BioEssays. ,vol. 17, pp. 491- 500 ,(1995) , 10.1002/BIES.950170605
Robert C. Piper, J. Paul Luzio, CUPpling calcium to lysosomal biogenesis Trends in Cell Biology. ,vol. 14, pp. 471- 473 ,(2004) , 10.1016/J.TCB.2004.07.010
James Deeds, Frank Cronin, Lyn M. Duncan, Patterns of melastatin mRNA expression in melanocytic tumors Human Pathology. ,vol. 31, pp. 1346- 1356 ,(2000) , 10.1016/S0046-8177(00)80003-9