A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer.
作者： Wei Wu He , Peter J. Sciavolino , John Wing , Meena Augustus , Peter Hudson
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摘要: We have isolated a prostate-specific gene (NKX3.1) in humans that is homologous to the Drosophila NK homeobox family. Northern blot analyses indicate this expressed at high levels adult prostate and much lower level testis, but little or not all several other tissues. In an androgen-dependent carcinoma line, LNCaP, NKX3.1 mRNA basal was increased markedly upon androgen stimulation; undetectable human tumor cell lines including two androgen-independent lines. The maps chromosome band 8p21, region frequently reported undergo loss of heterozygosity associated with tissue dedifferentiation responsiveness during progression cancer. Based on these data we propose candidate for playing role opposing processes androgen-driven differentiation prostatic
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