Hypercalcaemia – presentation and management

摘要: Hypercalcaemia is a common disorder normally caused by primary hyperparathyroidism (PHPT) or malignancy. A proportion of cases present as an emergency, which carries significant mortality. Emergency management hypercalcaemia based on intravenous rehydration with normal saline but when this inadequate, bisphosphonate therapy used; more recently the novel anti-resorbtive agent denosumab has been shown to have useful role in treatment. It estimated that up 10% all PHPT presenting under age 45 years underlying genetic predisposition; nine potentially causative genes are now recognised and may be screened routine clinical practice. Although parathyroidectomy only curative treatment for PHPT, indicated minority cases. Many can adequately managed conservatively guidance from 4th international workshop asymptomatic updated consensus statement.