Women who develop ovarian cancer show an increase in serum calcium and a decrease in serum albumin. A longitudinal study in the Janus Serum Bank Cohort

摘要: Abstract Background Ovarian cancer is associated with high serum calcium and low albumin in clinical epidemiologic studies. Whether predispose to ovarian or reflect existing unclear. Objective Test the hypothesis that increases decreases women who develop cancer. Methods Two hundred four donated sera Janus Serum Bank Norway pre- post-diagnosis of cancer, donations separated by approximately 14 years. We measured these calculated albumin-corrected calcium. Sera were adjusted for patient age storage time. Results Post-diagnosis, mean age- storage-adjusted increased, from 2.53 2.68 mmol/L (p  Conclusions These data support are biomarkers extant Longitudinal changes may be useful early detection.