Molecular Pathogenesis of Endometrial and Ovarian Cancer

摘要: Pregnancy, breastfeeding, and oral contraceptive pill use interrupt menstrual cycles reduce endometrial ovarian cancer risk. This suggests the importance of turnover within Mullerian tissues, where accumulation mutations in p53 PTEN has been correlated with number cycles. The most common type (Type I) is endometrioid molecular abnormalities include PTEN, KRAS β-catenin. Type I precursor Endometrial Intraepithelial Neoplasia which displays defects. II (whose precursors are less clear) includes serous clear cell tumors alteration mutation. For cancer, histopathologic types parallel serous, mucinous, endometrioid, cell; some features also shared. frequent high grade that often mutation its lesions may originate from normal-appearing fallopian tube epithelium contains a "signature". Mutations KRAS, BRAF described low cancers these cortical inclusion cysts. A consideration other pathogenetic features, like epidemiology histopathology, provide better understanding cancer.