Atypical fibroxanthoma and pleomorphic dermal sarcoma

摘要: Atypical fibroxanthoma (AFX) or undifferentiated pleomorphic sarcoma (UPS) is a rare malignant neoplastic disease of the skin. At beginning 1960s AFX was described as an independent entity and superficial variant fibrous histiocytoma (MFH). Since then, many controversies on classification have arisen mainly because in cases dedifferentiated neoplasms from other origins were falsely diagnosed AFX. A relevant deep expansion, invasion nerves vessels presence tumor necrosis are being typical for UPS; however, first-line they represent risk factors recurrence. In view clinical histological features it meaningful to consider UPS one disease. recent years studies molecular pathological background attempted make better neoplasm, without able so far name certain specific histopathological characteristic. The AFX/UPS still essence morphological immunohistochemical diagnosis by exclusion.