CGH analysis shows genetic similarities and differences in atypical fibroxanthoma and undifferentiated high grade pleomorphic sarcoma.
作者： Philipp U Heitz , Angela Baer , Bruno Paredes , Daniela Mihic-Probst , Paul Komminoth
DOI: 10.5167/UZH-111580
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摘要: Background: Atypical fibroxanthoma (AFX) and undifferentiated high grade pleomorphic sarcoma (UpS) are histologically very similar, if not identical. However, they differ significantly in clinical outcome. Materials Methods: We used comparative genomic hybridization (CGH) to screen 24 AFX 12 UpS for alterations. Results: DNA copy number changes were observed 20/24 all UpS. The most frequent alterations occurring with comparable frequency both tumors deletions on chromosomes 9p 13q. also detected statistically significant differences of genetic between the two concerning 1q, 3p, 5q, 11p, 11q, gains 7q, 12q level 5p 11q. Conclusion: Despite their similar histology, show clear This might contribute different biological behavior tumors. On other hand similarities 13q suggest a common pathogenetic pathway.
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