Mastabol induced acute cholestasis: A case report

摘要: A 26-year-old male presented with three weeks of jaundice after the self-initiation injectable anabolic steroid, Mastabol [Dromastanolone Di-Propionate (17 beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one propionate)]. He reported dark urine, light stools, and pruritus. denied abdominal pain, intravenous drug use, intranasal cocaine, blood transfusions, newly placed tattoos, or sexually transmitted diseases. used alcohol sparingly. Physical exam revealed deep scleral icterus. The liver was palpable 2 cm below right costal margin no ascites. peak bilirubin 23.6 mg/dL, alkaline phosphatase 441 units/L, aspartate aminotransferase/alanine aminotransferase were 70 units/L 117 respectively. working diagnosis acute intrahepatic cholestasis made. Liver biopsy a centrilobular insult neutrophilic infiltrates Ito cell hyperplasia consistent induced cholestasis. patient’s clinical symptoms resolved his enzymes, bilirubin, normalized. Anabolic steroids 17 alpha carbon substitutions have been associated bland variety cholestatic injury little hepatocellular injury. Cholestasis, under these circumstances, may be secondary to binding drugs canalicular membrane transporters, accumulation toxic bile acids from pump failure, genetic defects in transport proteins. is an injectable, beta hydroxyl compound alkyl groups at position. As such, it has potential effects on liver. This first known case Mastabol-induced It highlights need for physicians consider such widely available substances when faced hepatic unclear etiology.