Colonic bacterial activity determines the symptoms in people with fructose-malabsorption.

摘要: Background/Aim. This study was performed to find a parameter discriminate symptomatic from asymptomatic subjects with fructose-malabsorption. Patients and Methods : Thirty-four (12m,22f ; average age, 28.6 years range 16-60) were investigated after an overnight fast. After intake of 25g fructose, H 2 -tests carried out. Endexspiratory breath samples taken before the ingestion tested sugar at 30 minute intervals over hour period. Hydrogen determination immediately sampling. Results considered pathological if there rise in hydrogen 20ppm twofold increase initial value. Aerobic anaerobic cultures stool bacteria set incubated 0.5g fructose. Among 34 healthy controls, 13 malabsorbers (38%) detected. Out these malabsorbers, 6 (46%) reported gastrointestinal concomitant symptoms. Symptomatic fructose-malabsorption showed comparable levels. The disappearance rate fructose significantly elevated group compared asymptomatic, but only culture. Conclusion activity colonic bacteria, discriminating enhances importance differential diagnosis people non-specific abdominal complaints. Antibiotic therapy severe cases should be therapeutical approach. Moreover results may support role nutritional carbohydrates pathogenesis diseases.