Prostate apoptosis response-4 and tumor suppression: it's not just about apoptosis anymore.

摘要: The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an inducer, increasing and sometimes bewildering, new roles for Par-4 are being reported. These include ability to regulate autophagy, senescence, metastasis. This growing range of responses is reflected by our understanding the various mechanisms through which can function. In this review, we summarize existing knowledge on suppressive mechanisms, discuss how interaction with different regulators influence cell fate. review also highlights secretory pathway that emerged likely discussion clinical implications.