Development of a Hydroxyapatite/Collagen Nanocomposite as a Medical Device:

摘要: The effect of cross-linking a hydroxyapatite/collagen (HA/Col) nanocomposite, in which HA nanocrystals and collagen fibers are aligned like natural bone by self-organization mechanism between vitro, on mechanical properties was examined. influence degree cross-linking, as well rhBMP-2 preadsorption to the composite substitution pattern rate with bone, In Experiment 1, anterior fusion carried out at C3-C4 vertebrae 10 dogs they were implanted follows: without adsorbed (three dogs), (two dogs). Implants removed from each dog for histology determinations after 12, 16, 24 weeks non-rhBMP-treated groups, 16 rhBMP-treated groups. 2, HA/Col composites both pretreatment into defect 20 mm made central part tibiae (N = 3 group). As control, defects remained implantation 3). allowed walk using an Ilizarov extra skeletal fixator. implants one group. effective controlling strength bioresorbability. A "self-organization process" implant surface resulted formation remodeling units around implant. Radiographic histological findings suggest that combined treatment molecules may be very suitable replacement existing ceramic systems cervical spine, inlay grafting weight-bearing sites.